Table 4: Results of stability of DAS in human plasma under different storage conditions.

DASATINIB
Storage Condition Nominal Conc. (ng/mL) Conc. Found mean ± SD (ng/mL) CV (%) RE (%)
Autosampler stabilitya 3 3.17 ± 0.12 3.63 5.70
320 337.06 ± 7.81 2.32 5.33
Short-term plasma stabilityb 3 3.20 ± 0.12 3.65 6.67
320 341.87 ± 6.95 2.03 6.84
Long-term stabilityc 3 3.24 ± 0.12 3.63 8.18
320 342.75 ± 9.09 2.65 7.11
Freeze-thaw stabilityc 3 3.05 ± 0.09 2.80 1.63
320 325.64 ± 4.41 1.35 1.76

RE: Relative Error (Accuracy); CV: Coefficient of Variation (Precision); SD: Standard Deviation; aKept at autosampler temperature, 10 ℃; bStored at room temperature; cStored at -70 ℃.