Table 4: Results of stability of DAS in human plasma under different storage conditions.
DASATINIB | ||||
Storage Condition | Nominal Conc. (ng/mL) | Conc. Found mean ± SD (ng/mL) | CV (%) | RE (%) |
Autosampler stabilitya | 3 | 3.17 ± 0.12 | 3.63 | 5.70 |
320 | 337.06 ± 7.81 | 2.32 | 5.33 | |
Short-term plasma stabilityb | 3 | 3.20 ± 0.12 | 3.65 | 6.67 |
320 | 341.87 ± 6.95 | 2.03 | 6.84 | |
Long-term stabilityc | 3 | 3.24 ± 0.12 | 3.63 | 8.18 |
320 | 342.75 ± 9.09 | 2.65 | 7.11 | |
Freeze-thaw stabilityc | 3 | 3.05 ± 0.09 | 2.80 | 1.63 |
320 | 325.64 ± 4.41 | 1.35 | 1.76 |
RE: Relative Error (Accuracy); CV: Coefficient of Variation (Precision); SD: Standard Deviation; aKept at autosampler temperature, 10 ℃; bStored at room temperature; cStored at -70 ℃.