Table 3: Results of matrix effects for dasatinib (n = 6).
Plasma QC Low | Plasma QC High | ||||||||||
Mean Peak Area | Matrix Factor | Mean Peak Area IS (n = 6) | IS Matrix Factor | IS Normalized Matrix Factor | Mean Peak Area | Matrix Factor | Mean Peak Area IS (n = 6) | IS Matrix Factor | IS Normalized Matrix Factor | ||
Pure Solution | 21123.83 | - | 347032.50 | - | - | Pure Solution | 2389447.50 | - | 347032.50 | - | - |
Matrix 1 | 19708.33 | 0.93 | 365374.33 | 1.05 | 0.87 | Matrix 1 | 2554665.50 | 1.07 | 365374.33 | 1.05 | 1.06 |
Matrix 2 | 20253.17 | 0.96 | 384316.00 | 1.11 | 0.87 | Matrix 2 | 2936468.50 | 1.23 | 384316.00 | 1.11 | 1.11 |
Matrix 3 | 22970.17 | 1.09 | 437570.33 | 1.26 | 0.86 | Matrix 3 | 3178715.17 | 1.33 | 437570.33 | 1.26 | 1.06 |
Matrix 4 | 22732.67 | 1.08 | 433044.33 | 1.25 | 0.86 | Matrix 4 | 2841594.17 | 1.19 | 433044.33 | 1.25 | 0.95 |
Matrix 5 | 23380.50 | 1.11 | 434474.83 | 1.25 | 0.88 | Matrix 5 | 2826883.17 | 1.18 | 434474.83 | 1.25 | 0.95 |
Matrix 6 | 23868.50 | 1.13 | 417903.33 | 1.2 | 0.94 | Matrix 6 | 2870188.67 | 1.20 | 417903.33 | 1.20 | 1.00 |
Mean IS Normalized Matrix Factor | 0.88 | Mean IS Normalized Matrix Factor | 1.013 | ||||||||
CV (%) | 3.29 | CV (%) | 6.18 |